{
  "schema": "swarmlabs-parity-report/1.0",
  "generated_at_utc": "2026-10-11T01:55:45Z",
  "purpose": "Wet-lab anchor parity assessment — compares engine oracle outputs against literature-anchored parameter ranges",
  "summary": {
    "total_anchors": 19,
    "total_sources": 36,
    "total_doi": 3,
    "independence_ratio": 0.5278,
    "parity_grades": {
      "STRONG": 0,
      "MODERATE": 3,
      "LITERATURE_CONSENSUS": 3,
      "SINGLE_SOURCE": 13
    },
    "oracle_bounds_check": {
      "params_checked": 7,
      "in_bounds": 5,
      "out_of_bounds": 2,
      "pass_rate": 0.7143
    },
    "gate_ledger": {
      "PASS": 91,
      "MARGINAL": 3,
      "REFUTED": 1,
      "total": 0
    },
    "trust_surface": {
      "rubric_full_pass": 62,
      "coverage_ok": 93,
      "sharpness_ok": 81,
      "experimental_ground_truth": 0,
      "note": "0 real experimental ground truth — all evidence is literature-consensus or synthetic"
    }
  },
  "anchors": [
    {
      "key": "ecoli_glucose_Ks",
      "label": "E. coli / 葡萄糖 半饱和常数 Ks",
      "unit": "g/L",
      "literature_range": {
        "lo": 3e-05,
        "hi": 0.005
      },
      "mid_value": 0.002515,
      "n_sources": 4,
      "doi_count": 0,
      "independence_ratio": 1.0,
      "n_scenarios": 7,
      "scenario_keys": [
        "microbio_monod",
        "micro_ecoli_glucose",
        "micro_mle_ecoli_monod",
        "micro_doe_ecoli_monod",
        "micro_uq_ecoli_monod",
        "micro_sobol_ecoli",
        "micro_pirt_ecoli"
      ],
      "scenario_verdicts": [
        {
          "key": "microbio_monod",
          "verdict": "PASS",
          "gate": "PROCEED",
          "r2": 0.9997
        },
        {
          "key": "micro_ecoli_glucose",
          "verdict": "PASS",
          "gate": "PROCEED",
          "r2": 0.9922
        },
        {
          "key": "micro_mle_ecoli_monod",
          "verdict": "PASS",
          "gate": "PROCEED",
          "r2": 0.9989
        },
        {
          "key": "micro_doe_ecoli_monod",
          "verdict": "PASS",
          "gate": "PROCEED",
          "r2": 0.9983
        },
        {
          "key": "micro_uq_ecoli_monod",
          "verdict": "PASS",
          "gate": "PROCEED",
          "r2": 0.9966
        },
        {
          "key": "micro_sobol_ecoli",
          "verdict": "PASS",
          "gate": "PROCEED",
          "r2": 0.9944
        },
        {
          "key": "micro_pirt_ecoli",
          "verdict": "PASS",
          "gate": "PROCEED",
          "r2": 0.9999
        }
      ],
      "oracle_bounds_check": {
        "oracle_check": "out_of_bounds",
        "bounds": [
          0.02,
          2.0
        ],
        "anchor_value": 0.002515,
        "in_bounds": false
      },
      "parity_grade": "LITERATURE_CONSENSUS",
      "note": "真实生物学上 Ks 跨 167× 是可证的（生理适应），但**所有**独立来源都低于 5 mg/L；高于此值的场景参数与文献共识不符"
    },
    {
      "key": "ecoli_glucose_mu_max",
      "label": "E. coli / 葡萄糖 μmax",
      "unit": "h^-1",
      "literature_range": {
        "lo": 0.6,
        "hi": 1.4
      },
      "mid_value": 1.0,
      "n_sources": 4,
      "doi_count": 0,
      "independence_ratio": 1.0,
      "n_scenarios": 7,
      "scenario_keys": [
        "microbio_monod",
        "micro_ecoli_glucose",
        "micro_mle_ecoli_monod",
        "micro_doe_ecoli_monod",
        "micro_uq_ecoli_monod",
        "micro_sobol_ecoli",
        "micro_pirt_ecoli"
      ],
      "scenario_verdicts": [
        {
          "key": "microbio_monod",
          "verdict": "PASS",
          "gate": "PROCEED",
          "r2": 0.9997
        },
        {
          "key": "micro_ecoli_glucose",
          "verdict": "PASS",
          "gate": "PROCEED",
          "r2": 0.9922
        },
        {
          "key": "micro_mle_ecoli_monod",
          "verdict": "PASS",
          "gate": "PROCEED",
          "r2": 0.9989
        },
        {
          "key": "micro_doe_ecoli_monod",
          "verdict": "PASS",
          "gate": "PROCEED",
          "r2": 0.9983
        },
        {
          "key": "micro_uq_ecoli_monod",
          "verdict": "PASS",
          "gate": "PROCEED",
          "r2": 0.9966
        },
        {
          "key": "micro_sobol_ecoli",
          "verdict": "PASS",
          "gate": "PROCEED",
          "r2": 0.9944
        },
        {
          "key": "micro_pirt_ecoli",
          "verdict": "PASS",
          "gate": "PROCEED",
          "r2": 0.9999
        }
      ],
      "oracle_bounds_check": {
        "oracle_check": "in_bounds",
        "bounds": [
          0.02,
          2.0
        ],
        "anchor_value": 1.0,
        "in_bounds": true
      },
      "parity_grade": "LITERATURE_CONSENSUS",
      "note": "最小培养基 MG1655 约 0.6–0.7；富培养基 / B/r 可达 1.0–1.4"
    },
    {
      "key": "ecoli_glucose_maintenance",
      "label": "E. coli / 葡萄糖 维持系数 m_s",
      "unit": "g/(gDW·h)",
      "literature_range": {
        "lo": 0.051,
        "hi": 0.083
      },
      "mid_value": 0.067,
      "n_sources": 3,
      "doi_count": 0,
      "independence_ratio": 1.0,
      "n_scenarios": 1,
      "scenario_keys": [
        "micro_pirt_ecoli"
      ],
      "scenario_verdicts": [
        {
          "key": "micro_pirt_ecoli",
          "verdict": "PASS",
          "gate": "PROCEED",
          "r2": 0.9999
        }
      ],
      "oracle_bounds_check": {
        "oracle_check": "in_bounds",
        "bounds": [
          0.001,
          10.0
        ],
        "anchor_value": 0.067,
        "in_bounds": true
      },
      "parity_grade": "LITERATURE_CONSENSUS",
      "note": "按场景自称的菌株 MG1655 取值：Nanchen 2006 0.067 ± 0.016。若放宽到全部 9 株 E. coli，观测跨度为 0.020–0.068，即 m_s=0.02 恰落在物种观测下限 —— 判 NEAR 而非 CONTRADICTED。仅锚定 micro_pirt_ecoli：其他 Monod 场景的 m 虽写在 PAPER_PARAMS 里，但不进入 μ(S) 表达式，对 oracle 输出零影响，无法从输出反推。"
    },
    {
      "key": "cerevisiae_glucose_mu_max",
      "label": "S. cerevisiae / 葡萄糖 μmax",
      "unit": "h^-1",
      "literature_range": {
        "lo": 0.31,
        "hi": 0.6
      },
      "mid_value": 0.45499999999999996,
      "n_sources": 4,
      "doi_count": 1,
      "independence_ratio": 1.0,
      "n_scenarios": 2,
      "scenario_keys": [
        "micro_cerevisiae_ethanol",
        "micro_crabtree_cerevisiae"
      ],
      "scenario_verdicts": [
        {
          "key": "micro_cerevisiae_ethanol",
          "verdict": "PASS",
          "gate": "PROCEED",
          "r2": 0.9999
        },
        {
          "key": "micro_crabtree_cerevisiae",
          "verdict": "PASS",
          "gate": "PROCEED",
          "r2": 0.9978
        }
      ],
      "oracle_bounds_check": {
        "oracle_check": "in_bounds",
        "bounds": [
          0.001,
          20.0
        ],
        "anchor_value": 0.45499999999999996,
        "in_bounds": true
      },
      "parity_grade": "MODERATE",
      "note": "0.31（低值）– 0.60（Bader 表）；Kompala 发酵途径 0.45"
    },
    {
      "key": "cerevisiae_glucose_Ks",
      "label": "S. cerevisiae / 葡萄糖 Ks",
      "unit": "g/L",
      "literature_range": {
        "lo": 0.001,
        "hi": 0.18
      },
      "mid_value": 0.0905,
      "n_sources": 4,
      "doi_count": 1,
      "independence_ratio": 1.0,
      "n_scenarios": 1,
      "scenario_keys": [
        "micro_cerevisiae_ethanol"
      ],
      "scenario_verdicts": [
        {
          "key": "micro_cerevisiae_ethanol",
          "verdict": "PASS",
          "gate": "PROCEED",
          "r2": 0.9999
        }
      ],
      "oracle_bounds_check": {
        "oracle_check": "in_bounds",
        "bounds": [
          0.001,
          20.0
        ],
        "anchor_value": 0.0905,
        "in_bounds": true
      },
      "parity_grade": "MODERATE",
      "note": "1–180 mg/L，7.2× 跨度源于葡萄糖转运体切换（Hxt6/7 高亲和 vs Hxt1/3 低亲和）"
    },
    {
      "key": "ecoli_thermal_D60",
      "label": "E. coli 热死灭 D 值 @60°C",
      "unit": "s",
      "literature_range": {
        "lo": 25,
        "hi": 132
      },
      "mid_value": 78.5,
      "n_sources": 4,
      "doi_count": 1,
      "independence_ratio": 1.0,
      "n_scenarios": 1,
      "scenario_keys": [
        "micro_thermal_death"
      ],
      "scenario_verdicts": [
        {
          "key": "micro_thermal_death",
          "verdict": "PASS",
          "gate": "PROCEED",
          "r2": 1.0
        }
      ],
      "oracle_bounds_check": {
        "oracle_check": "in_bounds",
        "bounds": [
          60.0,
          100.0
        ],
        "anchor_value": 78.5,
        "in_bounds": true
      },
      "parity_grade": "MODERATE",
      "note": "31.5 s（人乳，Morgan 1988）– 118 s（Fellows 表）– 132 s（单株最大值，Nechifor 2013）"
    },
    {
      "key": "ammonia_haber_bosch_yield",
      "label": "Haber-Bosch 氨合成转化率 @ 400-500°C 100bar",
      "unit": "%",
      "literature_range": {
        "lo": 5.0,
        "hi": 25.0
      },
      "mid_value": 15.0,
      "n_sources": 1,
      "doi_count": 0,
      "independence_ratio": 1.0,
      "n_scenarios": 0,
      "scenario_keys": [],
      "scenario_verdicts": [],
      "oracle_bounds_check": null,
      "parity_grade": "SINGLE_SOURCE",
      "note": "31 条 Haber-Bosch Fe 催化剂实测行（400-500°C，100 bar）；温度升高 100°C 转化率翻倍。"
    },
    {
      "key": "adsorption_acid_carbon_capacity",
      "label": "活性炭对亚甲基蓝的吸附容量 @ 25°C",
      "unit": "mg/g",
      "literature_range": {
        "lo": 25.0,
        "hi": 280.0
      },
      "mid_value": 152.5,
      "n_sources": 1,
      "doi_count": 0,
      "independence_ratio": 1.0,
      "n_scenarios": 1,
      "scenario_keys": [
        "chem_langmuir"
      ],
      "scenario_verdicts": [
        {
          "key": "chem_langmuir",
          "verdict": "PASS",
          "gate": "PROCEED",
          "r2": 0.9979
        }
      ],
      "oracle_bounds_check": {
        "oracle_check": "out_of_bounds",
        "bounds": [
          0.1,
          10.0
        ],
        "anchor_value": 152.5,
        "in_bounds": false
      },
      "parity_grade": "SINGLE_SOURCE",
      "note": "30 条活性炭-亚甲基蓝实测行；50 mg/L 底物浓度下 45 mg/g，200 mg/L 下 150 mg/g，1000 mg/L 下 280 mg/g（Langmuir 上渐近）。"
    },
    {
      "key": "bioreactor_ecoli_biomass",
      "label": "E. coli 批次反应器生物量（g/L, 37°C pH7）",
      "unit": "g/L",
      "literature_range": {
        "lo": 1.0,
        "hi": 12.0
      },
      "mid_value": 6.5,
      "n_sources": 1,
      "doi_count": 0,
      "independence_ratio": 1.0,
      "n_scenarios": 0,
      "scenario_keys": [],
      "scenario_verdicts": [],
      "oracle_bounds_check": null,
      "parity_grade": "SINGLE_SOURCE",
      "note": "30 条批次实测行；24h 时间窗内生物量 1-12 g/L，随接种量与时间单调。"
    },
    {
      "key": "enzyme_lipase_activity",
      "label": "脂肪酶活 @ pH 7.5 温度响应",
      "unit": "UM/mg",
      "literature_range": {
        "lo": 0.4,
        "hi": 9.0
      },
      "mid_value": 4.7,
      "n_sources": 1,
      "doi_count": 0,
      "independence_ratio": 1.0,
      "n_scenarios": 0,
      "scenario_keys": [],
      "scenario_verdicts": [],
      "oracle_bounds_check": null,
      "parity_grade": "SINGLE_SOURCE",
      "note": "30 条脂肪酶实测行；最适 37°C 4.5 UM/mg，25°C 2.2，50°C 2.8（失活前）。"
    },
    {
      "key": "corrosion_carbon_steel_rate",
      "label": "碳钢腐蚀速率 @ 25°C (3.5%NaCl / 1M H2SO4)",
      "unit": "mm/y",
      "literature_range": {
        "lo": 0.17,
        "hi": 1.39
      },
      "mid_value": 0.7799999999999999,
      "n_sources": 1,
      "doi_count": 0,
      "independence_ratio": 1.0,
      "n_scenarios": 0,
      "scenario_keys": [],
      "scenario_verdicts": [],
      "oracle_bounds_check": null,
      "parity_grade": "SINGLE_SOURCE",
      "note": "30 条碳钢腐蚀实测行；3.5% NaCl 25°C 15 mm/y 0.17 mm/y，1M H2SO4 120 mm/y 1.39 mm/y（8× 加速）。"
    },
    {
      "key": "photoFenton_removal_efficiency",
      "label": "光-Fenton 亚甲基蓝去除率 @ 25°C 60 min",
      "unit": "%",
      "literature_range": {
        "lo": 40.0,
        "hi": 96.0
      },
      "mid_value": 68.0,
      "n_sources": 1,
      "doi_count": 0,
      "independence_ratio": 1.0,
      "n_scenarios": 0,
      "scenario_keys": [],
      "scenario_verdicts": [],
      "oracle_bounds_check": null,
      "parity_grade": "SINGLE_SOURCE",
      "note": "30 条光-Fenton 去除率实测行；无光 60 min 40-50%，加可见光升至 85-95%。"
    },
    {
      "key": "membrane_nf_rejection",
      "label": "NF90 纳滤膜对 NaCl/Na2SO4 的截留率",
      "unit": "%",
      "literature_range": {
        "lo": 92.0,
        "hi": 98.0
      },
      "mid_value": 95.0,
      "n_sources": 1,
      "doi_count": 0,
      "independence_ratio": 1.0,
      "n_scenarios": 0,
      "scenario_keys": [],
      "scenario_verdicts": [],
      "oracle_bounds_check": null,
      "parity_grade": "SINGLE_SOURCE",
      "note": "30 条 NF90 纳滤实测行；1000 mg/L NaCl @5bar 92%，Na2SO4 98%（二价离子截留更高）。"
    },
    {
      "key": "pcr_amplification_efficiency",
      "label": "PCR 扩增效率 @ 95°C 解链 35 循环",
      "unit": "%",
      "literature_range": {
        "lo": 82.0,
        "hi": 96.0
      },
      "mid_value": 89.0,
      "n_sources": 1,
      "doi_count": 0,
      "independence_ratio": 1.0,
      "n_scenarios": 0,
      "scenario_keys": [],
      "scenario_verdicts": [],
      "oracle_bounds_check": null,
      "parity_grade": "SINGLE_SOURCE",
      "note": "30 条 PCR 实测行；模板 10^4 copies 22.5 Cq 效率 95%，10^2 copies 29.1 Cq 效率 94%。"
    },
    {
      "key": "perovskite_solar_pce",
      "label": "钙钛矿太阳能电池功率转换效率",
      "unit": "%",
      "literature_range": {
        "lo": 8.5,
        "hi": 23.5
      },
      "mid_value": 16.0,
      "n_sources": 1,
      "doi_count": 0,
      "independence_ratio": 1.0,
      "n_scenarios": 0,
      "scenario_keys": [],
      "scenario_verdicts": [],
      "oracle_bounds_check": null,
      "parity_grade": "SINGLE_SOURCE",
      "note": "30 条钙钛矿太阳能电池实测行；薄膜制备工艺差异导致 PCE 8.5-23.5% 跨度。"
    },
    {
      "key": "battery_energy_density",
      "label": "锂离子电池体积能量密度",
      "unit": "Wh/L",
      "literature_range": {
        "lo": 95.0,
        "hi": 160.0
      },
      "mid_value": 127.5,
      "n_sources": 1,
      "doi_count": 0,
      "independence_ratio": 1.0,
      "n_scenarios": 0,
      "scenario_keys": [],
      "scenario_verdicts": [],
      "oracle_bounds_check": null,
      "parity_grade": "SINGLE_SOURCE",
      "note": "29 条锂电实测行；三元正极 140 Wh/L 均值，硅负极 95-120 Wh/L。"
    },
    {
      "key": "distillation_separation_factor",
      "label": "精馏塔分离因子（乙醇-水）",
      "unit": "dimensionless",
      "literature_range": {
        "lo": 0.79,
        "hi": 0.98
      },
      "mid_value": 0.885,
      "n_sources": 1,
      "doi_count": 0,
      "independence_ratio": 1.0,
      "n_scenarios": 0,
      "scenario_keys": [],
      "scenario_verdicts": [],
      "oracle_bounds_check": null,
      "parity_grade": "SINGLE_SOURCE",
      "note": "30 条乙醇精馏实测行；95% 塔板数下分离因子 0.79-0.98。"
    },
    {
      "key": "flocculation_removal_rate",
      "label": "絮凝去除率 @ 30 min 沉降",
      "unit": "%",
      "literature_range": {
        "lo": 75.0,
        "hi": 96.0
      },
      "mid_value": 85.5,
      "n_sources": 1,
      "doi_count": 0,
      "independence_ratio": 1.0,
      "n_scenarios": 0,
      "scenario_keys": [],
      "scenario_verdicts": [],
      "oracle_bounds_check": null,
      "parity_grade": "SINGLE_SOURCE",
      "note": "30 条絮凝实测行；PAM 5 mg/L 75-85%，PAC 30 mg/L 90-96%。"
    },
    {
      "key": "combustion_efficiency_gcc",
      "label": "燃气轮机燃烧效率 @ 100% 负荷",
      "unit": "%",
      "literature_range": {
        "lo": 88.0,
        "hi": 95.0
      },
      "mid_value": 91.5,
      "n_sources": 1,
      "doi_count": 0,
      "independence_ratio": 1.0,
      "n_scenarios": 0,
      "scenario_keys": [],
      "scenario_verdicts": [],
      "oracle_bounds_check": null,
      "parity_grade": "SINGLE_SOURCE",
      "note": "30 条燃气轮机实测行；1800-3080 °C 燃烧室温度下效率 88-95%。"
    }
  ],
  "honesty_note": "This report compares engine oracle parameter ranges against literature-anchored ranges. It does NOT constitute experimental ground truth validation. experimental_ground_truth=0 remains: no independent laboratory measurement has been used to validate any scenario output. Parity grade STRONG requires ≥2 DOI sources AND oracle value within bounds. The absence of experimental ground truth is the single largest gap in this project's evidence chain.",
  "recommendations": [
    "Acquire ≥3 real experimental datasets (growth curves, fermentation batches) to set experimental_ground_truth ≥ 3",
    "Add measured_value fields to anchors with actual lab measurements (not just literature ranges)",
    "Build executable parity protocol: submit oracle predictions → compare with lab measurements → grade agreement",
    "Target micro_ecoli_glucose (most anchored, 7 scenarios) for first real-lab validation"
  ]
}