{ "name": "SwarmLabs verification gate ledger", "version": "2026-09-15", "generated_at_utc": "2026-10-11T01:57:22Z", "standard": "ASME V&V 10-2019 / FDA CM&S report outline", "build": { "complete": true, "source": "frontend_fixed/reports/index.json", "registry_total": 95, "optional_deps": { "rdkit_available": true, "dropped_molecular_scenarios": [] }, "dropped_scenarios": [], "note": "本次构建未丢弃任何场景（registry_total == total），账本覆盖注册表中的全部场景。" }, "policy": { "noise_floor": 0.03, "nominal_coverage": 0.95, "pass": "R2>=0.9 and one-sided coverage>=0.9", "marginal": "R2>=0.7 and coverage>=0.8", "refuted": "below the MARGINAL bars", "kappa": "variance-scale, only widens uncertainty, capped at 40", "gate_map": { "PASS": "PROCEED", "MARGINAL": "PROCEED_WITH_HUMAN_CHECK", "REFUTED": "BLOCK_AUTONOMOUS_ACTION", "ERROR": "BLOCK_AUTONOMOUS_ACTION" }, "note": "Confidence below the MARGINAL bar blocks autonomous action on that scenario. Verifying a model's OWN predictions at arbitrary inputs requires the engine and is served by the MCP server (mcp/swarmlabs_vv_server.py) and, on the published held-out test sets, by POST /v3/verify. This ledger answers the static question \"can this scenario be trusted right now?\" for any HTTP agent." }, "counts": { "PASS": 91, "MARGINAL": 3, "REFUTED": 1, "ERROR": 0 }, "total": 95, "n_blocked": 1, "n_human_check_required": 3, "blocked": [ "mol_suzuki_yield" ], "human_check_required": [ "eco_lv_peak_ratio", "neuro_hh_spike_amplitude", "neuro_lif_fi" ], "calibration": { "method": "linear_softmax_rlcd_log_likelihood", "steps": 3000, "lr": 0.05, "ece": 0.0116, "ece_references": { "laya_zero_shot": 0.466, "laya_refit_temperature": 0.081, "jev_1_13": 0.246 }, "label_distribution": { "PASS": 91, "MARGINAL": 3, "REFUTED": 1, "UNVALIDATED": 0 }, "mean_log_likelihood": -0.012, "mean_p_pass": 0.9502, "n_scenarios": 95, "note": "ECE (Expected Calibration Error) 度量报告概率与真实频率的匹配程度；越低越好。当前 62/62 PASS 训练集高度不均衡，ECE 偏低是分布内验证，不代表生产泛化能力。等有 MARGINAL/REFUTED 场景自然出现，训练集会自动变均衡。" }, "provenance": { "engine": { "git_commit": "b34acfc460e213f8b8cb2d35b520dbfb97e11419", "git_commit_source": "local .git HEAD", "git_commit_binding": "advisory only — pushes go through the Contents API, which does not advance local HEAD, so this may name a commit that does not contain the current engine state. all_digest is the authoritative binding.", "n_modules": 91, "core": { "surrogate.py": "43231fddc23f1d92f19418281c3305faf19b0b6c37fa30b362a268d6e3139cd9", "microbiology_full.py": "ea84e841b999d5cb76f7a952e858fc2c9c648fc3a08a0a55dcc9997076d7ff20", "scenarios_extra.py": "55df6e9584fb21bf83b2aa634caa136d03e154e1928e6d64202892c50d0259cf", "verification_gate.py": "734105b2fae53a8541d472e48b58c095ffadfd8e4c10cd32249f5f1f894810f5", "guard.py": "277a861f204ee8fbf4250f2df05a1a64fe080fbf0421ed72176cacdfc4e0149b", "wet_lab_anchors.py": "6980b62210640290066c88e09561829b1e0a500255abe3b848cbfefa2dfca2fe", "report_generator.py": "8b91cf0c967fc07db76a1483c0683d37f76883717350a3808c200bcdd281aa47" }, "core_digest": "b620c2f76c095852a703684457368c9157415b4bd14eef2ca066e69925dfbca3", "all_digest": "9c823f1fb0c01e0e30b97b1c057ac838a97eaa42c60e453c41402ec070da1e4e" }, "oracle": { "files": { "microbiology_full.py": "ea84e841b999d5cb76f7a952e858fc2c9c648fc3a08a0a55dcc9997076d7ff20", "scenarios_extra.py": "55df6e9584fb21bf83b2aa634caa136d03e154e1928e6d64202892c50d0259cf", "surrogate.py": "43231fddc23f1d92f19418281c3305faf19b0b6c37fa30b362a268d6e3139cd9" }, "digest": "67055b8337450b6b62ee1d9aa071482d4c86c33c934ff86dd12ae662784c1b92" }, "report_index_sha256": "63f8a33aa7a1499edfdb02f44dc9393853261040236751a3a4fb01591a9bea00", "builder": "scripts/build_gate_ledger.py", "note": "判定钉死在 engine.all_digest 上：引擎或场景 oracle 任一改动都会改变该摘要，ledger_is_stale() 随即报 stale。这不是说旧结论错，而是说它尚未针对当前引擎重算过。" }, "scenarios": { "bio_logistic": { "gate": "PROCEED", "verdict": "PASS", "rationale": "out-of-sample R²=1.000 ≥ 0.9, coverage=1.000 ≥ 0.9（校准安全，保守亦可）", "domain": "Biology/Population Dynamics", "published": "Logistic Growth N(t)=K/(1+Ae^{-rt}), K=100,r=0.6,A=19", "dim": 1, "n_train": 30, "n_test": 40, "uncertainty": { "noise_floor": 0.03, "nominal_coverage": 0.95, "coverage": 1.0, "calibration_scale_kappa": 1.0, "cal_err": 0.05, "r2": 1.0, "r2_core": 1.0, "rmse_rel": 0.0021 }, "high_freq": false, "replication_passed": false, "report": { "html": "/reports/html/bio_logistic.html", "json": "/reports/json/bio_logistic.json", "docx": "/reports/docx/bio_logistic.docx" } }, "chem_bet": { "gate": "PROCEED", "verdict": "PASS", "rationale": "out-of-sample R²=1.000 ≥ 0.9, coverage=1.000 ≥ 0.9（校准安全，保守亦可）", "domain": "chemical / BET 多层吸附等温线", "published": "Brunauer-Emmett-Teller (1938) 多层吸附等温线，q=q_m·bC/[(1−C/C_m)(1+(b−1)C)]", "dim": 4, "n_train": 60, "n_test": 60, "uncertainty": { "noise_floor": 0.03, "nominal_coverage": 0.95, "coverage": 1.0, "calibration_scale_kappa": 1.0, "cal_err": 0.05, "r2": 0.9999, "r2_core": 1.0, "rmse_rel": 0.0092 }, "high_freq": false, "replication_passed": false, "report": { "html": "/reports/html/chem_bet.html", "json": "/reports/json/chem_bet.json", "docx": "/reports/docx/chem_bet.docx" } }, "chem_freundlich": { "gate": "PROCEED", "verdict": "PASS", "rationale": "out-of-sample R²=1.000 ≥ 0.9, coverage=1.000 ≥ 0.9（校准安全，保守亦可）", "domain": "chemical / Freundlich 经验吸附等温线", "published": "Freundlich (1926) q=K·C^(1/n)，经验指数 1/n∈(0,1]（多相非饱和吸附）", "dim": 3, "n_train": 80, "n_test": 60, "uncertainty": { "noise_floor": 0.03, "nominal_coverage": 0.95, "coverage": 1.0, "calibration_scale_kappa": 1.0, "cal_err": 0.05, "r2": 1.0, "r2_core": 1.0, "rmse_rel": 0.0069 }, "high_freq": false, "replication_passed": false, "report": { "html": "/reports/html/chem_freundlich.html", "json": "/reports/json/chem_freundlich.json", "docx": "/reports/docx/chem_freundlich.docx" } }, "chem_langmuir": { "gate": "PROCEED", "verdict": "PASS", "rationale": "out-of-sample R²=0.998 ≥ 0.9, coverage=0.950 ≥ 0.9（校准安全，保守亦可）", "domain": "Chemical/Adsorption Isotherm (Langmuir 1916)", "published": "Langmuir 1916 Adsorption Isotherm θ=KP/(1+KP); K Takes Representative Value 1.5 (Adsorption Isotherm Literature Range 0.1–10)", "dim": 1, "n_train": 30, "n_test": 40, "uncertainty": { "noise_floor": 0.03, "nominal_coverage": 0.95, "coverage": 0.95, "calibration_scale_kappa": 1.0593, "cal_err": 0.0, "r2": 0.9979, "r2_core": 0.9981, "rmse_rel": 0.0461 }, "high_freq": false, "replication_passed": false, "report": { "html": "/reports/html/chem_langmuir.html", "json": "/reports/json/chem_langmuir.json", "docx": "/reports/docx/chem_langmuir.docx" } }, "chem_reactor_conversion": { "gate": "PROCEED", "verdict": "PASS", "rationale": "out-of-sample R²=1.000 ≥ 0.9, coverage=1.000 ≥ 0.9（校准安全，保守亦可）", "domain": "Chemistry / First-Order Reactor Conversion (Arrhenius Kinetics, 2D)", "published": "First-Order CSTR/PFR Conversion X=1-exp(-k0·exp(-Ea/RT)·τ); Ea takes representative 30 kJ/mol, k0 is normalized to ensure X(410K,τ=5)≈0.9 (Homogeneous Reaction Kinetics Literature Range; Levenspiel 1999 Reactor Design)", "dim": 2, "n_train": 50, "n_test": 60, "uncertainty": { "noise_floor": 0.03, "nominal_coverage": 0.95, "coverage": 1.0, "calibration_scale_kappa": 1.0, "cal_err": 0.05, "r2": 1.0, "r2_core": 1.0, "rmse_rel": 0.0027 }, "high_freq": false, "replication_passed": false, "report": { "html": "/reports/html/chem_reactor_conversion.html", "json": "/reports/json/chem_reactor_conversion.json", "docx": "/reports/docx/chem_reactor_conversion.docx" } }, "cheminfo_hydration": { "gate": "PROCEED", "verdict": "PASS", "rationale": "out-of-sample R²=1.000 ≥ 0.9, coverage=1.000 ≥ 0.9（校准安全，保守亦可）", "domain": "cheminformatics", "published": "642 分子真实实验值（freesolv），线性响应面 oracle 从 200 训练分子 lstsq 拟合；目标变量：exp_hydration_free_energy_kcal_mol", "dim": 7, "n_train": 80, "n_test": 40, "uncertainty": { "noise_floor": 0.03, "nominal_coverage": 0.95, "coverage": 1.0, "calibration_scale_kappa": 1.0, "cal_err": 0.05, "r2": 0.9997, "r2_core": 0.9996, "rmse_rel": 0.0174 }, "high_freq": false, "replication_passed": false, "report": { "html": "/reports/html/cheminfo_hydration.html", "json": "/reports/json/cheminfo_hydration.json", "docx": "/reports/docx/cheminfo_hydration.docx" } }, "cheminfo_logD": { "gate": "PROCEED", "verdict": "PASS", "rationale": "out-of-sample R²=1.000 ≥ 0.9, coverage=1.000 ≥ 0.9（校准安全，保守亦可）", "domain": "cheminformatics", "published": "4200 分子真实实验值（chembl_lipophilicity），线性响应面 oracle 从 800 训练分子 lstsq 拟合；目标变量：exp_logD", "dim": 8, "n_train": 80, "n_test": 40, "uncertainty": { "noise_floor": 0.03, "nominal_coverage": 0.95, "coverage": 1.0, "calibration_scale_kappa": 1.0, "cal_err": 0.05, "r2": 0.9998, "r2_core": 0.9997, "rmse_rel": 0.0156 }, "high_freq": false, "replication_passed": false, "report": { "html": "/reports/html/cheminfo_logD.html", "json": "/reports/json/cheminfo_logD.json", "docx": "/reports/docx/cheminfo_logD.docx" } }, "cheminfo_logS": { "gate": "PROCEED", "verdict": "PASS", "rationale": "out-of-sample R²=1.000 ≥ 0.9, coverage=1.000 ≥ 0.9（校准安全，保守亦可）", "domain": "cheminformatics", "published": "1128 分子真实实验值（esol_delaney），线性响应面 oracle 从 400 训练分子 lstsq 拟合；目标变量：exp_logS", "dim": 9, "n_train": 80, "n_test": 40, "uncertainty": { "noise_floor": 0.03, "nominal_coverage": 0.95, "coverage": 1.0, "calibration_scale_kappa": 1.0, "cal_err": 0.05, "r2": 0.9999, "r2_core": 0.9999, "rmse_rel": 0.0082 }, "high_freq": false, "replication_passed": true, "report": { "html": "/reports/html/cheminfo_logS.html", "json": "/reports/json/cheminfo_logS.json", "docx": "/reports/docx/cheminfo_logS.docx" } }, "cheminfo_pIC50": { "gate": "PROCEED", "verdict": "PASS", "rationale": "out-of-sample R²=1.000 ≥ 0.9, coverage=1.000 ≥ 0.9（校准安全，保守亦可）", "domain": "cheminformatics", "published": "1513 分子真实实验值（bace），线性响应面 oracle 从 400 训练分子 lstsq 拟合；目标变量：exp_pIC50", "dim": 7, "n_train": 80, "n_test": 40, "uncertainty": { "noise_floor": 0.03, "nominal_coverage": 0.95, "coverage": 1.0, "calibration_scale_kappa": 1.0, "cal_err": 0.05, "r2": 0.9996, "r2_core": 0.9994, "rmse_rel": 0.0207 }, "high_freq": false, "replication_passed": true, "report": { "html": "/reports/html/cheminfo_pIC50.html", "json": "/reports/json/cheminfo_pIC50.json", "docx": "/reports/docx/cheminfo_pIC50.docx" } }, "eco_lv_peak_ratio": { "gate": "PROCEED_WITH_HUMAN_CHECK", "verdict": "MARGINAL", "rationale": "R²=0.734 ≥ 0.7 且 coverage=0.967 ≥ 0.8，但有一项未达 PASS 门槛", "domain": "ecology", "published": "Lotka-Volterra 捕食者-猎物 ODE，RK4 数值积分", "dim": 4, "n_train": 60, "n_test": 30, "uncertainty": { "noise_floor": 0.03, "nominal_coverage": 0.95, "coverage": 0.967, "calibration_scale_kappa": 17.8949, "cal_err": 0.017, "r2": 0.7338, "r2_core": 0.4313, "rmse_rel": 0.5162 }, "high_freq": true, "replication_passed": false, "report": { "html": "/reports/html/eco_lv_peak_ratio.html", "json": "/reports/json/eco_lv_peak_ratio.json", "docx": "/reports/docx/eco_lv_peak_ratio.docx" } }, "eco_nicholson_bailey": { "gate": "PROCEED", "verdict": "PASS", "rationale": "out-of-sample R²=0.960 ≥ 0.9, coverage=0.933 ≥ 0.9（校准安全，保守亦可）", "domain": "ecology / Nicholson-Bailey 宿主-寄生物平衡", "published": "Nicholson-Bailey (1935) 宿主-寄生物平衡 H*=m/(b·a)（离散世代，含周期解）", "dim": 5, "n_train": 60, "n_test": 60, "uncertainty": { "noise_floor": 0.03, "nominal_coverage": 0.95, "coverage": 0.933, "calibration_scale_kappa": 5.069, "cal_err": 0.017, "r2": 0.9596, "r2_core": 0.9915, "rmse_rel": 0.201 }, "high_freq": false, "replication_passed": false, "report": { "html": "/reports/html/eco_nicholson_bailey.html", "json": "/reports/json/eco_nicholson_bailey.json", "docx": "/reports/docx/eco_nicholson_bailey.docx" } }, "eco_ricker_population": { "gate": "PROCEED", "verdict": "PASS", "rationale": "out-of-sample R²=1.000 ≥ 0.9, coverage=1.000 ≥ 0.9（校准安全，保守亦可）", "domain": "ecology / Ricker 种群调控（10 代）", "published": "Ricker (1957) N_{t+1}=N·e^{r(1−N/K)}，密度制约调控的经典离散模型", "dim": 3, "n_train": 80, "n_test": 60, "uncertainty": { "noise_floor": 0.03, "nominal_coverage": 0.95, "coverage": 1.0, "calibration_scale_kappa": 1.0, "cal_err": 0.05, "r2": 1.0, "r2_core": 1.0, "rmse_rel": 0.0046 }, "high_freq": false, "replication_passed": false, "report": { "html": "/reports/html/eco_ricker_population.html", "json": "/reports/json/eco_ricker_population.json", "docx": "/reports/docx/eco_ricker_population.docx" } }, "energy_ccpp_output": { "gate": "PROCEED", "verdict": "PASS", "rationale": "out-of-sample R²=1.000 ≥ 0.9, coverage=1.000 ≥ 0.9（校准安全，保守亦可）", "domain": "energy", "published": "NASA CCPP 联合循环电厂 6 年 9,568 行实测；4 环境特征 → 功率输出 MW；oracle = 训练集 lstsq 线性响应面", "dim": 4, "n_train": 80, "n_test": 40, "uncertainty": { "noise_floor": 0.03, "nominal_coverage": 0.95, "coverage": 1.0, "calibration_scale_kappa": 1.0, "cal_err": 0.05, "r2": 1.0, "r2_core": 1.0, "rmse_rel": 0.0056 }, "high_freq": false, "replication_passed": false, "report": { "html": "/reports/html/energy_ccpp_output.html", "json": "/reports/json/energy_ccpp_output.json", "docx": "/reports/docx/energy_ccpp_output.docx" } }, "energy_isothermal_work": { "gate": "PROCEED", "verdict": "PASS", "rationale": "out-of-sample R²=1.000 ≥ 0.9, coverage=1.000 ≥ 0.9（校准安全，保守亦可）", "domain": "energy / 等温可逆膨胀功", "published": "可逆等温膨胀功 W=nRT·ln(V₂/V₁)（理想气体，定义式，无近似）", "dim": 5, "n_train": 60, "n_test": 60, "uncertainty": { "noise_floor": 0.03, "nominal_coverage": 0.95, "coverage": 1.0, "calibration_scale_kappa": 1.0, "cal_err": 0.05, "r2": 1.0, "r2_core": 1.0, "rmse_rel": 0.0055 }, "high_freq": false, "replication_passed": false, "report": { "html": "/reports/html/energy_isothermal_work.html", "json": "/reports/json/energy_isothermal_work.json", "docx": "/reports/docx/energy_isothermal_work.docx" } }, "energy_rankine_efficiency": { "gate": "PROCEED", "verdict": "PASS", "rationale": "out-of-sample R²=1.000 ≥ 0.9, coverage=1.000 ≥ 0.9（校准安全，保守亦可）", "domain": "energy / Rankine 循环实际效率与 Carnot 之比", "published": "简化 Rankine 循环效率：η=1−T_c/T_h 乘以部件效率因子（火电厂「可逆进程」度量）", "dim": 4, "n_train": 60, "n_test": 60, "uncertainty": { "noise_floor": 0.03, "nominal_coverage": 0.95, "coverage": 1.0, "calibration_scale_kappa": 1.0, "cal_err": 0.05, "r2": 1.0, "r2_core": 1.0, "rmse_rel": 0.0048 }, "high_freq": false, "replication_passed": false, "report": { "html": "/reports/html/energy_rankine_efficiency.html", "json": "/reports/json/energy_rankine_efficiency.json", "docx": "/reports/docx/energy_rankine_efficiency.docx" } }, "fin_merton_call_div": { "gate": "PROCEED", "verdict": "PASS", "rationale": "out-of-sample R²=1.000 ≥ 0.9, coverage=1.000 ≥ 0.9（校准安全，保守亦可）", "domain": "finance / Merton 连续红利欧式看涨", "published": "Merton (1973) C=S·e^(−qT)N(d1)−K·e^(−rT)N(d2)，d1 含连续红利率 q（BS 的推广）", "dim": 6, "n_train": 120, "n_test": 80, "uncertainty": { "noise_floor": 0.03, "nominal_coverage": 0.95, "coverage": 1.0, "calibration_scale_kappa": 1.0, "cal_err": 0.05, "r2": 0.9999, "r2_core": 0.9999, "rmse_rel": 0.009 }, "high_freq": false, "replication_passed": true, "report": { "html": "/reports/html/fin_merton_call_div.html", "json": "/reports/json/fin_merton_call_div.json", "docx": "/reports/docx/fin_merton_call_div.docx" } }, "heat_radiation_flux": { "gate": "PROCEED", "verdict": "PASS", "rationale": "out-of-sample R²=0.999 ≥ 0.9, coverage=0.950 ≥ 0.9（校准安全，保守亦可）", "domain": "heat conduction (physics-informed) / Stefan-Boltzmann 净辐射换热", "published": "Stefan-Boltzmann 定律 εσA(T1⁴−T2⁴)，σ=5.670374419e-8 W/m²K⁴（CODATA 2018）", "dim": 4, "n_train": 60, "n_test": 60, "uncertainty": { "noise_floor": 0.03, "nominal_coverage": 0.95, "coverage": 0.95, "calibration_scale_kappa": 1.0, "cal_err": 0.0, "r2": 0.9991, "r2_core": 0.9999, "rmse_rel": 0.0306 }, "high_freq": false, "replication_passed": false, "report": { "html": "/reports/html/heat_radiation_flux.html", "json": "/reports/json/heat_radiation_flux.json", "docx": "/reports/docx/heat_radiation_flux.docx" } }, "heat_series_resistance": { "gate": "PROCEED", "verdict": "PASS", "rationale": "out-of-sample R²=1.000 ≥ 0.9, coverage=1.000 ≥ 0.9（校准安全，保守亦可）", "domain": "heat conduction (physics-informed) / 串联热阻稳态导热", "published": 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"/reports/html/micro_fedbatch_ecoli.html", "json": "/reports/json/micro_fedbatch_ecoli.json", "docx": "/reports/docx/micro_fedbatch_ecoli.docx" } }, "micro_foam_dynamics": { "gate": "PROCEED", "verdict": "PASS", "rationale": "out-of-sample R²=1.000 ≥ 0.9, coverage=1.000 ≥ 0.9（校准安全，保守亦可）", "domain": "微生物 / micro_foam_dynamics", "published": "Krebes & Scharaschkin 1996 (foam in bioreactors)", "dim": 2, "n_train": 50, "n_test": 60, "uncertainty": { "noise_floor": 0.03, "nominal_coverage": 0.95, "coverage": 1.0, "calibration_scale_kappa": 1.0, "cal_err": 0.05, "r2": 0.9998, "r2_core": 0.9999, "rmse_rel": 0.0134 }, "high_freq": true, "replication_passed": false, "report": { "html": "/reports/html/micro_foam_dynamics.html", "json": "/reports/json/micro_foam_dynamics.json", "docx": "/reports/docx/micro_foam_dynamics.docx" } }, "micro_gene_expression": { "gate": "PROCEED", "verdict": "PASS", "rationale": "out-of-sample R²=1.000 ≥ 0.9, coverage=1.000 ≥ 0.9（校准安全，保守亦可）", "domain": "微生物 / micro_gene_expression", "published": "Bashor & Meyer 2017 (gene expression dynamics)", "dim": 2, "n_train": 50, "n_test": 60, "uncertainty": { "noise_floor": 0.03, "nominal_coverage": 0.95, "coverage": 1.0, "calibration_scale_kappa": 1.0, "cal_err": 0.05, "r2": 0.9998, "r2_core": 0.9998, "rmse_rel": 0.0138 }, "high_freq": false, "replication_passed": true, "report": { "html": "/reports/html/micro_gene_expression.html", "json": "/reports/json/micro_gene_expression.json", "docx": "/reports/docx/micro_gene_expression.docx" } }, "micro_haldane_2d": { "gate": "PROCEED", "verdict": "PASS", "rationale": "out-of-sample R²=1.000 ≥ 0.9, coverage=1.000 ≥ 0.9（校准安全，保守亦可）", "domain": "微生物 / micro_haldane_2d", "published": "Haldane 1956 (2D)", "dim": 2, "n_train": 50, "n_test": 60, "uncertainty": { "noise_floor": 0.03, "nominal_coverage": 0.95, "coverage": 1.0, "calibration_scale_kappa": 1.0, "cal_err": 0.05, "r2": 0.9999, "r2_core": 0.9999, "rmse_rel": 0.0081 }, "high_freq": false, 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0.9, coverage=1.000 ≥ 0.9（校准安全，保守亦可）", "domain": "微生物 / micro_heavy_metal_ecoli", "published": "Kumar et al. 2012 (heavy metal stress)", "dim": 1, "n_train": 30, "n_test": 40, "uncertainty": { "noise_floor": 0.03, "nominal_coverage": 0.95, "coverage": 1.0, "calibration_scale_kappa": 1.0, "cal_err": 0.05, "r2": 1.0, "r2_core": 1.0, "rmse_rel": 0.0078 }, "high_freq": false, "replication_passed": true, "report": { "html": "/reports/html/micro_heavy_metal_ecoli.html", "json": "/reports/json/micro_heavy_metal_ecoli.json", "docx": "/reports/docx/micro_heavy_metal_ecoli.docx" } }, "micro_immobilized_cell": { "gate": "PROCEED", "verdict": "PASS", "rationale": "out-of-sample R²=0.998 ≥ 0.9, coverage=0.917 ≥ 0.9（校准安全，保守亦可）", "domain": "微生物 / micro_immobilized_cell", "published": "Shuler & Kargi 2002 (immobilized cells)", "dim": 2, "n_train": 50, "n_test": 60, "uncertainty": { "noise_floor": 0.03, "nominal_coverage": 0.95, "coverage": 0.917, "calibration_scale_kappa": 1.0461, "cal_err": 0.033, 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"/reports/docx/micro_lactococcus_lactose.docx" } }, "micro_lag_ecoli": { "gate": "PROCEED", "verdict": "PASS", "rationale": "out-of-sample R²=1.000 ≥ 0.9, coverage=1.000 ≥ 0.9（校准安全，保守亦可）", "domain": "微生物 / micro_lag_ecoli", "published": "Baranyi & Roberts 1994 IJF 10:300 (lag phase)", "dim": 1, "n_train": 30, "n_test": 40, "uncertainty": { "noise_floor": 0.03, "nominal_coverage": 0.95, "coverage": 1.0, "calibration_scale_kappa": 1.0, "cal_err": 0.05, "r2": 0.9999, "r2_core": 0.9999, "rmse_rel": 0.0085 }, "high_freq": false, "replication_passed": true, "report": { "html": "/reports/html/micro_lag_ecoli.html", "json": "/reports/json/micro_lag_ecoli.json", "docx": "/reports/docx/micro_lag_ecoli.docx" } }, "micro_lifecycle_ecoli": { "gate": "PROCEED", "verdict": "PASS", "rationale": "out-of-sample R²=1.000 ≥ 0.9, coverage=1.000 ≥ 0.9（校准安全，保守亦可）", "domain": "微生物 / micro_lifecycle_ecoli", "published": "Baranyi 1993 (full lifecycle)", "dim": 1, "n_train": 30, "n_test": 40, "uncertainty": { 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"/reports/html/micro_methanobacterium_methane.html", "json": "/reports/json/micro_methanobacterium_methane.json", "docx": "/reports/docx/micro_methanobacterium_methane.docx" } }, "micro_mixed_substrate": { "gate": "PROCEED", "verdict": "PASS", "rationale": "out-of-sample R²=0.997 ≥ 0.9, coverage=1.000 ≥ 0.9（校准安全，保守亦可）", "domain": "微生物 / micro_mixed_substrate", "published": "Roels 1983 (mixed substrate utilization)", "dim": 2, "n_train": 50, "n_test": 60, "uncertainty": { "noise_floor": 0.03, "nominal_coverage": 0.95, "coverage": 1.0, "calibration_scale_kappa": 1.0, "cal_err": 0.05, "r2": 0.9974, "r2_core": 0.9932, "rmse_rel": 0.0512 }, "high_freq": false, "replication_passed": true, "report": { "html": "/reports/html/micro_mixed_substrate.html", "json": "/reports/json/micro_mixed_substrate.json", "docx": "/reports/docx/micro_mixed_substrate.docx" } }, "micro_mle_ecoli_monod": { "gate": "PROCEED", "verdict": "PASS", "rationale": "out-of-sample R²=0.999 ≥ 0.9, coverage=1.000 ≥ 0.9（校准安全，保守亦可）", "domain": "微生物 / micro_mle_ecoli_monod", "published": "Vogel 2004 (Bayesian estimation)", "dim": 1, "n_train": 30, "n_test": 40, "uncertainty": { "noise_floor": 0.03, "nominal_coverage": 0.95, "coverage": 1.0, "calibration_scale_kappa": 1.0, "cal_err": 0.05, "r2": 0.9989, "r2_core": 0.9209, "rmse_rel": 0.0303 }, "high_freq": false, "replication_passed": true, "report": { "html": "/reports/html/micro_mle_ecoli_monod.html", "json": "/reports/json/micro_mle_ecoli_monod.json", "docx": "/reports/docx/micro_mle_ecoli_monod.docx" } }, "micro_osmotic_ecoli": { "gate": "PROCEED", "verdict": "PASS", "rationale": "out-of-sample R²=1.000 ≥ 0.9, coverage=1.000 ≥ 0.9（校准安全，保守亦可）", "domain": "微生物 / micro_osmotic_ecoli", "published": "Rose 2008 Bacterial Osmotic Stress", "dim": 1, "n_train": 30, "n_test": 40, "uncertainty": { "noise_floor": 0.03, "nominal_coverage": 0.95, "coverage": 1.0, "calibration_scale_kappa": 1.0, "cal_err": 0.05, "r2": 0.9996, "r2_core": 0.9995, "rmse_rel": 0.0192 }, "high_freq": true, "replication_passed": false, "report": { "html": "/reports/html/micro_osmotic_ecoli.html", "json": "/reports/json/micro_osmotic_ecoli.json", "docx": "/reports/docx/micro_osmotic_ecoli.docx" } }, "micro_oxidative_stress": { "gate": "PROCEED", "verdict": "PASS", "rationale": "out-of-sample R²=1.000 ≥ 0.9, coverage=1.000 ≥ 0.9（校准安全，保守亦可）", "domain": "微生物 / micro_oxidative_stress", "published": "Imlay 2008 (oxidative stress)", "dim": 1, "n_train": 30, "n_test": 40, "uncertainty": { "noise_floor": 0.03, "nominal_coverage": 0.95, "coverage": 1.0, "calibration_scale_kappa": 1.0, "cal_err": 0.05, "r2": 1.0, "r2_core": 1.0, "rmse_rel": 0.0064 }, "high_freq": false, "replication_passed": true, "report": { "html": "/reports/html/micro_oxidative_stress.html", "json": "/reports/json/micro_oxidative_stress.json", "docx": "/reports/docx/micro_oxidative_stress.docx" } }, "micro_oxygen_2d": { "gate": "PROCEED", "verdict": "PASS", "rationale": "out-of-sample R²=1.000 ≥ 0.9, coverage=1.000 ≥ 0.9（校准安全，保守亦可）", "domain": "微生物 / micro_oxygen_2d", "published": "Shuler & Kargi 2002 (O2 2D)", "dim": 2, "n_train": 50, "n_test": 60, "uncertainty": { "noise_floor": 0.03, "nominal_coverage": 0.95, "coverage": 1.0, "calibration_scale_kappa": 1.0, "cal_err": 0.05, "r2": 0.9997, "r2_core": 0.9989, "rmse_rel": 0.0178 }, "high_freq": false, "replication_passed": false, "report": { "html": "/reports/html/micro_oxygen_2d.html", "json": "/reports/json/micro_oxygen_2d.json", "docx": "/reports/docx/micro_oxygen_2d.docx" } }, "micro_oxygen_ecoli": { "gate": "PROCEED", "verdict": "PASS", "rationale": "out-of-sample R²=0.995 ≥ 0.9, coverage=0.975 ≥ 0.9（校准安全，保守亦可）", "domain": "微生物 / micro_oxygen_ecoli", "published": "Shuler & Kargi 2002 (oxygen limitation)", "dim": 1, "n_train": 30, "n_test": 40, "uncertainty": { "noise_floor": 0.03, "nominal_coverage": 0.95, "coverage": 0.975, "calibration_scale_kappa": 1.0, "cal_err": 0.025, "r2": 0.9949, "r2_core": 0.9998, "rmse_rel": 0.0713 }, "high_freq": true, "replication_passed": false, "report": { "html": "/reports/html/micro_oxygen_ecoli.html", "json": "/reports/json/micro_oxygen_ecoli.json", "docx": "/reports/docx/micro_oxygen_ecoli.docx" } }, "micro_ph_control": { "gate": "PROCEED", "verdict": "PASS", "rationale": "out-of-sample R²=1.000 ≥ 0.9, coverage=1.000 ≥ 0.9（校准安全，保守亦可）", "domain": "微生物 / micro_ph_control", "published": "Shuler & Kargi 2002 (pH control)", "dim": 2, "n_train": 50, "n_test": 60, "uncertainty": { "noise_floor": 0.03, "nominal_coverage": 0.95, "coverage": 1.0, "calibration_scale_kappa": 1.0, "cal_err": 0.05, "r2": 0.9999, "r2_core": 0.9999, "rmse_rel": 0.0105 }, "high_freq": false, "replication_passed": true, "report": { "html": "/reports/html/micro_ph_control.html", "json": "/reports/json/micro_ph_control.json", "docx": "/reports/docx/micro_ph_control.docx" } }, "micro_phage_infection": { "gate": "PROCEED", "verdict": "PASS", "rationale": "out-of-sample R²=1.000 ≥ 0.9, coverage=1.000 ≥ 0.9（校准安全，保守亦可）", "domain": "微生物 / micro_phage_infection", "published": "Luria & Delbrück 1943 (phage infection)", "dim": 2, "n_train": 50, "n_test": 60, "uncertainty": { "noise_floor": 0.03, "nominal_coverage": 0.95, "coverage": 1.0, "calibration_scale_kappa": 1.0, "cal_err": 0.05, "r2": 1.0, "r2_core": 1.0, "rmse_rel": 0.0036 }, "high_freq": false, "replication_passed": false, "report": { "html": "/reports/html/micro_phage_infection.html", "json": "/reports/json/micro_phage_infection.json", "docx": "/reports/docx/micro_phage_infection.docx" } }, "micro_pirt_ecoli": { "gate": "PROCEED", "verdict": "PASS", "rationale": "out-of-sample R²=1.000 ≥ 0.9, coverage=1.000 ≥ 0.9（校准安全，保守亦可）", "domain": "微生物 / micro_pirt_ecoli", "published": "Pirt 1965 Newer Studies in Microbiology (Pirt maintenance)", "dim": 1, "n_train": 30, "n_test": 40, "uncertainty": { "noise_floor": 0.03, "nominal_coverage": 0.95, "coverage": 1.0, "calibration_scale_kappa": 1.0, "cal_err": 0.05, "r2": 0.9999, "r2_core": 0.9255, "rmse_rel": 0.0118 }, "high_freq": false, "replication_passed": true, "report": { "html": "/reports/html/micro_pirt_ecoli.html", "json": "/reports/json/micro_pirt_ecoli.json", "docx": "/reports/docx/micro_pirt_ecoli.docx" } }, "micro_plasmid_stability": { "gate": "PROCEED", "verdict": "PASS", "rationale": "out-of-sample R²=1.000 ≥ 0.9, coverage=1.000 ≥ 0.9（校准安全，保守亦可）", "domain": "微生物 / micro_plasmid_stability", "published": "Stewart 1978 (plasmid stability)", "dim": 2, "n_train": 50, "n_test": 60, "uncertainty": { "noise_floor": 0.03, "nominal_coverage": 0.95, "coverage": 1.0, "calibration_scale_kappa": 1.0, "cal_err": 0.05, "r2": 1.0, "r2_core": 1.0, "rmse_rel": 0.0035 }, "high_freq": false, "replication_passed": true, "report": { "html": "/reports/html/micro_plasmid_stability.html", "json": "/reports/json/micro_plasmid_stability.json", "docx": "/reports/docx/micro_plasmid_stability.docx" } }, "micro_putida_toluene": { "gate": "PROCEED", "verdict": "PASS", "rationale": "out-of-sample R²=1.000 ≥ 0.9, coverage=1.000 ≥ 0.9（校准安全，保守亦可）", "domain": "微生物 / 假单胞菌甲苯降解（Andrews 底物抑制）", "published": "P. putida MT-2: μmax=0.35 h⁻¹, Ks=0.02 g/L, Ki(toluene)=2.5 g/L (Rothman et al. 1993)", "dim": 1, "n_train": 30, "n_test": 40, "uncertainty": { "noise_floor": 0.03, "nominal_coverage": 0.95, "coverage": 1.0, "calibration_scale_kappa": 1.0, "cal_err": 0.05, "r2": 0.9999, "r2_core": 0.9999, "rmse_rel": 0.0098 }, "high_freq": false, "replication_passed": true, "report": { "html": "/reports/html/micro_putida_toluene.html", "json": "/reports/json/micro_putida_toluene.json", "docx": "/reports/docx/micro_putida_toluene.docx" } }, "micro_quorum_ecoli": { "gate": "PROCEED", "verdict": "PASS", "rationale": "out-of-sample R²=1.000 ≥ 0.9, coverage=1.000 ≥ 0.9（校准安全，保守亦可）", "domain": "微生物 / micro_quorum_ecoli", "published": "Basler & Bassler 2011 (quorum sensing)", "dim": 1, "n_train": 30, "n_test": 40, "uncertainty": { "noise_floor": 0.03, "nominal_coverage": 0.95, "coverage": 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